Insulin resistance indexes as biomarkers of lifetime cardiovascular risk among adults from Peru

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dc.contributor.advisorHuancahuire Vega, SalomĆ³n
dc.contributor.authorRojas Humpire, Ricardo Josue
dc.date.accessioned2021-08-12T17:31:03Z
dc.date.available2021-08-12T17:31:03Z
dc.date.issued2021-07-15
dc.description.abstractBackground. Cardiovascular diseases (CVD) are the most prevalent cause of death from disease and disability in the world. Reliable markers are needed to assess and reduce cardiovascular risk. The aim of this study was to determine if insulin resistance indexes, triglycerides to HDL-cholesterol ratio (TG/HDL-c) and triglycerides to glucose index (TGI), are biomarkers for lifetime cardiovascular risk. Methods. This analytical cross-sectional study was performed in health workers from the Hospital de Huaycan in Peru. The QRISK model was used to measure lifetime cardiovascular risk. The association and diagnostic accuracy for insulin resistance indexes were determined using Poisson regression models and ROC curves with Youden index, respectively. Results. In total 291 adults (207 women and 84 men) were analyzed. In the multivariable analysis the 3rd tertil of TG/HDL-c (PRa:2.72, CI95% 1.13 - 6.57) and TGI (PRa:4.73, CI95% 1.56 - 14.31) increased significantly the lifetime cardiovascular risk compared to their 1st tertil. The cut-off values of TG/HDL-c was 2.64 (AUC:0.77), 3.90 (AUC:0.80) and 2.64 (AUC:0.74) for the overall population, men and women, respectively. Likewise, the cut-off values of TGI was 9.04 (AUC:0.80), 8.95 (AUC:0.79) and 9.04 (AUC:0.80) for the overall population, men and women, respectively. Conclusion. TG/HDL-c and TGI presented significant association with lifetime cardiovascular risk. However, TGI presented a stronger association than TG/HDL-c. Both TG/HDL-c and TGI are shown to be reliable markers for cardiovascular risk in adults.en_ES
dc.description.escuelaEscuela Profesional de Medicina Humanaen_ES
dc.description.lineadeinvestigacionEnfermedades no infecciosasen_ES
dc.description.sedeLIMAen_ES
dc.formatapplication/pdfen_ES
dc.identifier.urihttps://hdl.handle.net/20.500.12840/4656
dc.language.isoeng
dc.publisherUniversidad Peruana UniĆ³nen_ES
dc.publisher.countryPEen_ES
dc.rightsinfo:eu-repo/semantics/openAccessen_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/es/*
dc.subjectCardiovascular diseasesen_ES
dc.subjectInsulin resistanceen_ES
dc.subjectBiomarkersen_ES
dc.subjectPrimary preventionen_ES
dc.subject.ocdehttp://purl.org/pe-repo/ocde/ford#3.02.04en_ES
dc.titleInsulin resistance indexes as biomarkers of lifetime cardiovascular risk among adults from Peruen_ES
dc.typeinfo:eu-repo/semantics/bachelorThesisen_ES
renati.advisor.dni41407030
renati.advisor.orcidhttps://orcid.org/0000-0002-4848-4767en_ES
renati.author.dni47489506
renati.discipline912016en_ES
renati.jurorHuancahuire Vega, SalomĆ³n
renati.levelhttps://purl.org/pe-repo/renati/level#bachilleren_ES
renati.typehttp://purl.org/pe-repo/renati/type#trabajoDeInvestigacionen_ES
thesis.degree.disciplineMedicina Humanaen_ES
thesis.degree.grantorUniversidad Peruana UniĆ³n. Facultad de Ciencias Empresarialesen_ES
thesis.degree.nameBachiller en Medicina Humanaen_ES

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